教授/長聘副教授
隨著蛋白質組學研究的深入，迫切需要發展針對亞細胞蛋白質組的分離分析新技術。根據不同亞細胞蛋白質組的特點⛹🏿♂️，結合納米材料構建亞細胞蛋白質組研究核心方法。
圍繞生物對象開展分離分析新技術新方法新材料研究，特別是針對蛋白質與核酸的分離新材料等🧜♂️，發展修飾蛋白的分離、定性、定量和結構解析新技術和新方法，為蛋白質組學📸、蛋白質翻譯後修飾及其功能研究提供技術支持。
無創分子診斷對癌症的篩查、診斷和治療非常關鍵，是生物分離分析的重要研究方向。在已有分離分析新技術新方法以及外泌體研究等技術基礎上，結合國家戰略需求和實際臨床需要，發展用於癌症早期診斷、早期預警和早期幹預治療的新技術新途徑。
外泌體在癌症的發生發展過程中起著非常重要的作用，同時也是潛在的癌症診斷標誌物和治療載體。針對體液與細胞外泌體，發展分離分析新技術，開展外泌體蛋白質組及其翻譯後修飾研究，拓展外泌體的功能研究與臨床應用。
Wang, Z.Y., Wu, L.H., Guo, M., Zhu, J.Z., Zhao, J.Q., Wu., Y., Xiao, H., Zhang, Y., Activation of dimerized BRS3-EP3 suppresses melanoma cell migration through coupling G s protein, Fundamental Research 2024, Accepted.
Wang, H.Y., Zhang, Y., Wang, Z.Y., Zhang, L., Guo, M., Cao, C.X., Xiao, H., Deciphering nucleic acid binding proteome of mouse immune organs reveals hub proteins for aging, Mol. Cell. Proteomics 2023, 22(8):100611
Wu, L.H., Cui, J.H., Zhao, C.X., Wang, Z.Y., Lu, J.H., Li, S.S., Jia, J.P., Xiao, H., Zhang, Y., Discovery of Dimethyl Shikonin Oxime 5a, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Type 2 Diabetes Mellitus, J. Med. Chem. 2023, 66(12):8011-8029.
Jiang, X.T., Zhang, Y., Wang, H.Y., Wang, Z.Y., Hu, S., Cao, C.X., Xiao, H., In-Depth Metaproteomics Analysis of Oral Microbiome for Lung Cancer. Research. 2022, 2022: 9781578.
Sohail, A., Jiang, X.T., Wahid, A., Wang, H.Y., Cao, C.X., Xiao, H., Free-flow zone electrophoresis facilitated proteomics analysis of heterogeneous subpopulations in H1299 lung cancer cells. Anal. Chim. Acta 2022, 1227: 340306.
Zhang, B.H., Guo, M., Wang, H.Y., Wang, Z.Y., Zhang, L., Zhang, Y., Cao, C.X., Xiao, H., Metal organic framework nanomaterial based extraction and proteome analysis of membrane and membrane-associated proteins. Anal. Chem. 2021, 93(48):15922-15930.
Jiang, X.T., Liu, S., Zhang, Y., Ji, Y., Sohail, A., Cao, C.X., Wang, P., Xiao, H., Free-Flow Isoelectric Focusing for comprehensive separation and analysis of human salivary microbiome for lung cancer. Anal. Chem. 2020, 92(17):12017-12025
Liu, S., Jiang, X.T., Shang, Z., Ji, Y., Wang, H.Y., Wang, Z.Y., Wang, P., Zhang, Y., Xiao, H., N-glycan structures of target cancer biomarker characterized by two-dimensional gel electrophoresis and mass spectrometry. Anal. Chim. Acta 2020, 1123:18-27.
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