研究員
非2-酮糖是一類獨特的稀有糖類，能用於合成其它藥物的基本出發原料👲🏼。不同於一般的2-酮糖如：果糖、木酮糖🏭、山梨糖、核酮糖等糖類🛀，非2-酮糖是多元醇（對於六元醇而言）的第3位或者第4位羥基被氧化為酮基的一類酮糖😱，若對於五元醇🧑🏼🏫🤓，其第3位羥基被氧化為3-酮糖。研究氧化醋酸桿菌的膜結合的酶催化多元醇生成非2-酮糖的機理🍋📮，有助於EON体育4平台開發合成3-酮糖或者4-酮糖的新的酶學方法🩳。
解脂耶氏酵母具有豐富的合成其它功能化合物的途徑🏀，充分挖掘利用這些途徑能高效合成其它的功能化合物，比如木糖醇、大麻素💍、甜菊糖苷等🧭。EON体育4平台正集中研究力量進行這些功能化合物的研究👩👩👧👦。
通過對解脂耶氏酵母基因組、代謝組的研究🚶♀️，提高該酵母合成甘露醇的轉化率，阻斷副產物合成途徑，阻斷利用甘露醇的途徑🔨，提高其耐高溫發酵性能（如在35度下進行發酵）🛀🏼，構建合成甘露醇的“超級菌株”。
通過對解脂耶氏酵母基因組、代謝組的研究，提高該酵母合成赤蘚糖醇的轉化率🥡，阻斷副產物合成途徑🦪，阻斷利用赤蘚糖醇的途徑，提高其耐高溫發酵性能（如在35度下進行發酵），構建合成赤蘚糖醇的“超級菌株”🤬。
Zhang L, An J, Li L, Wang H, Liu D, Li N, Cheng HR, Deng Z. Highly Efficient Fructooligosaccharides Production by an Erythritol-Producing Yeast Yarrowialipolytica Displaying Fructosyltransferase. J Agric Food Chem.2016,18,64(19):3828-37.（通訊作者）🔏👫。
An J, Zhang L, Li L, Liu D, Cheng H, Wang H, Nawaz MZ, Cheng HR*, Deng Z. An Alternative Approach to Synthesizing Galactooligosaccharides by Cell-Surface Display of β-Galactosidase on Yarrowia lipolytica. J Agric Food Chem.2016,18,64(19):3819-27.（通訊作者）
Wang H, Li L, Zhang L, An J, Cheng HR*, Deng Z. Xylitol production from waste xylose mother liquor containing miscellaneous sugars and inhibitors: one-pot biotransformation byCandida tropicalisand recombinantBacillus subtilis.Microb Cell Fact.2016,16,15(1):82.（通訊作者）
Ning Li, Hengwei Wang, Huilin Cheng, Dawen Liu, Hairong Cheng*, Zixin Deng. An Integrated Approach to Producing High-purity Trehalose from Maltose by the YeastYarrowialipolyticaDisplaying Trehalose Synthase (TreS) on the Cell Surface.J. Agric. Food Chem.,2016,64(31), pp 6179–6187（通訊作者）
Siqi Wang, Hengwei Wang, JiyangLv, Zixin Deng, Hairong Cheng. Highly Efficient Erythritol Recovery from Waste Erythritol Mother Liquid by Yeast-mediated Biopurification. J. Agric. Food Chem.,2017,65:11020-11028.（通訊作者）
Huiling Cheng, Siqi Wang, Muhammad Bilal, Xuemei Ge, Can Zhang, Patrick Fickers and Hairong Cheng*. Identification, characterization of two NADPH-dependent erythrose reductases in the yeast Yarrowia lipolytica and improvement of erythritol productivity using metabolic engineering. Microbial Cell Factories, 2018,17:133. (通訊作者)
Ping Chi, Siqi Wang, Xuemei Ge, Muhammad Bilal, Patrick Fickers, Hairong Cheng*. Efficient D-threitol production by an engineered strain of Yarrowia lipolytica overexpressing xylitol dehydrogenase gene from Scheffersomyces stipitis. Biochemical Engineering Journal, 2019, 149 ,107259. (通訊作者)。
Producing Trehalose from Maltodextrin by the Erythritol-Producing Yeast Yarrowia lipolytica Co-displaying maltooligosyltrehalose synthase and maltooligosyltrehalose trehalohydrolase
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