曹博

    研究員

    • 電話:+86-021
    • 郵箱:caobosjtu@sjtu.edu.cn
    • 地址🤹🏽‍♂️:生物藥學樓4B-313
    • PI,博士生導師,國家優秀青年基金獲得者🧑🏽‍🚀,中央高校優秀青年團隊負責人。通過開發核酸組學新技術,挖掘新型表觀調控系統、作用機理、臨床診療新靶標等。科研成果發表在Nat Biotech, Nat Commun, PNAS, Angewandte等🏑。授權中美專利6項,商業轉化3項。

    學術經歷

    • 2015-2018 美國麻省理工EON4🫔,博士後
    • 2018-2019 新加坡SMART研究所,Research Scientist
    • 2019-2021 曲阜師範大學,教授
    • 2022-今 EON体育4🌞,長聘教軌副教授

    研究方向

    開發核酸組學研究新技術、發現臨床應用新靶標

    通過開發核酸組學新技術,系統挖掘臨床樣本中核酸代謝異常導致的多種疾病,為臨床診療提供新思路和新靶標

    DNA大分子的化學修飾

    解析新型DNA表觀遺傳修飾和化學損傷修復的代謝過程、生理功能👩‍💻、相互作用網絡等

    新型非編碼RNA資源挖掘

    鑒定未知新型非編碼RNA,尤其含有高度修飾RNA的生物合成、代謝網路🧖🏼、調控功能等

    代表論著

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      Hu J, Yim D, Ma D, Huber MS, Davis N, Bacusmo JM, Vermeulen S, Zhou J, Begley TJ, DeMott MS,   Levine SS, Crécy-Lagard V, Dedon PC*, Cao B*. Quantitative mapping of the cellular small RNA landscape with AQRNA-seq. Nat. Biotech. 2021 Aug;39(8):978-988.

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      Kaiser S, Byrne SR, Ammann G, Asadi Atoi P, Borland K, Brecheisen R, DeMott MS, Gehrke T, Hagelskamp F, Heiss M, Yoluc Y, Liu L, Zhang Q, Dedon PC, Cao B*, Kellner S*. Strategies to avoid artifacts in mass spectrometry-based epitranscriptome analyses. Angew Chem Int Ed Engl. 2021 Oct 25;60(44):23885-23893.

      •  

      Cao B*#, Wu X#,  Zhou J, Wu H, Liu L, Zhang Q, DeMott MS, Gu C, Wang L, You D*, Dedon PC*, Nick-seq for single-nucleotide resolution genomic maps of DNA modifications and damage, Nucleic Acids Res, 2020, 48(12), 6715–6725

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      Wu X#, Cao B#, Aquino P, Chiu TP, Chen C, Jiang S, Deng Z, Chen S, Rohs   R, Wang L, Galagan JE, Dedon PC*. Epigenetic competition reveals   density-dependent regulation and target site plasticity of phosphorothioate   epigenetics in bacteria. Proc Natl Acad Sci USA. 2020. Jun 23;117(25):14322-14330. 

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      Cao B #, Chen C#, DeMott MS, Cheng Q, Clark TA, Xiong X, Zheng X, Butty V, Levine SS, Yuan G, Boitano M, Luong K, Song Y, Zhou X, Deng Z, Turner SW, Korlach J, You D, Wang L, Chen S, Dedon PC. Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences. Nat Commun. 2014, 5, 3951.

    • •  

      Cao B, Cheng Q, Gu C, Yao F, DeMott MS, Zheng X, Deng Z, Dedon PC, You D*. Pathological phenotypes and in vivo DNA cleavage by unrestrained activity of a phosphorothioate-based restriction system in Salmonella. Mol Microbiol. 2014, 93 (4), 776-85.

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      Cheng Q#, Cao B#, Yao F, Li J, Deng Z, You D*. Regulation of DNA phosphorothioate modifications by the transcriptional regulator DptB in Salmonella. Mol Microbiol. 2015, 97 (6), 1186

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      Cao B, Zheng X, Cheng Q, Yao F, Zheng T, Ramesh Babu I, Zhou H, Dedon PC, You D*. In vitro analysis of phosphorothioate modification of DNA reveals substrate recognition by a multiprotein complex. Sci Rep. 2015, 5, 12513.

      •  

      Cao B, Yao F, Zheng X, Cui D, Shao Y, Zhu C, Deng Z, You D*. Genome mining of the biosynthetic gene cluster of the polyene macrolide antibiotic tetramycin and characterization of a P450 monooxygenase involved in the hydroxylation of the tetramycin B polyol segment. Chembiochem. 2012, 13 (15), 2234-42.

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      Kellner SM, DeMott MS, Cheng C, Russell B, Cao B, Dedon PC*. Oxidation of labile phosphorothioate DNA modifications leads to lethal genomic instability. Nat Chem Biol. 2017 Aug;13(8),888-894.

    • 國家自然科學基金面上項目👃🏼,2021-2024
    • 國家自然科學基金優青項目,2023-2025
    • 國家重點研發計劃子課題,2023-2027
    • 中央高校優秀青年團隊培育基金🍾,2023-2025

    承擔項目

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