研究員/長聘副教授
是對維持真核生物健康有關鍵作用的的一類亞細胞降解途徑。該通路以囊泡運輸的形式實現對胞內受損或冗余的大分子和細胞器的高效清除。研究表明👯♂️，細胞自噬在生物體生長發育、免疫防禦、細胞程序性死亡、腫瘤抑製等方面有非常重要的作用。本領域的研究興起於上世紀90年代🧑🏼🦳，現在是生命科學研究前沿發展最快的領域之一。
本實驗室的研究主要包括利用現代分子生物學、細胞生物學方法，尋找作用於自噬體形成過程的新基因🧑🏿💼👸🏽，進一步揭示自噬體形成的分子機理，理清上遊信號轉導網絡對細胞自噬的調節作用，研究細胞自噬在疾病發生過程中的作用📕，探索通過幹預細胞自噬減緩或治愈疾病的可行性。
He, CW, Cui, XF, Ma, SJ, Xu Q, Ran YP, Chen WZ, Mu JX, Li H, Zhu J, Gong Q, Xie Z*. Membrane recruitment of Atg8 by Hfl1 facilitates turnover of vacuolar membrane proteins in yeast cells approaching stationary phase. BMC Biol. 2021 Jun 04(1); 19:117.
Li D, Yang SG, He CW, Zhang ZT, Liang Y, Li H, Zhu J, Su X*, Gong Q*, Xie Z*. Excess diacylglycerol at the endoplasmic reticulum disrupts endomembrane homeostasis and autophagy. BMC Biol. 2020 Aug 28;18(1):107.
Zhu J, Zhang ZT, Tang SW, Zhao BS, Li H, Song JZ, Li D, Xie Z*. A Validated Set of Fluorescent-Protein-Based Markers for Major Organelles in Yeast (Saccharomyces cerevisiae). mBio. 2019 Sep 3;10(5). pii: e01691-19.
Zhu J, Deng S, Lu P, Bu W, Li T, Yu L*, Xie Z*. The Ccl1-Kin28 kinase complex regulates autophagy under nitrogen starvation. J Cell Sci. 2016 Jan1;129(1):135-44.
Li D, Song JZ, Li H, Shan MH, Liang Y, Zhu J, Xie Z*. Storage lipid synthesis is necessary for autophagy induced by nitrogen starvation. FEBS Lett. 2015 Jan 16;589(2):269-76.
Backues SK, Chen D, Ruan J, Xie Z*, Klionsky DJ*. Estimating the size and number of autophagic bodies by electron microscopy. Autophagy. 2014 Jan 1;10(1):155-64.
Yang J, Zhao Y, Ma K, Jiang FJ, Liao W, Zhang P, Zhou J, Tu B, Wang L, Kampinga HH, Xie Z*, Zhu WG*. Deficiency of hepatocystin induces autophagy through an mTOR-dependent pathway. Autophagy. 2011 Jul;7(7):748-59. )
Zou S, Chen Y, Liu Y, Segev N, Yu S, Liu Y, Min G, Ye M, Zeng Y, Zhu X, Hong B, Björn LO, Liang Y*, Li S* and Xie Z*. Trs130 participates in autophagy through GTPases Ypt31/32 in Saccharomyces cerevisiae. Traffic. 2013 Feb;14(2):233-46.
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