長聘教軌副教授
研究微生物個體在群體中的決策👩🏿🍼🪺，社會性行為🫙，以及潛在的在生物技術以及合成生物學中的應用價值。
充分應用自主開發的使能工具結合計算生物學設計構建可與重要生物活性化合物綠色智能製造，重要環境汙染物降解以及疾病治療領域對接的微生物細胞工廠🧑🏼💼。
基於CRISPR等的合成生物學工具深度開發，動態轉錄翻譯調控平臺的搭建等。
Chia, N., Lee, S.Y.* Tong, Y.*, Optogenetic tools for microbial synthetic biology. Biotechnol. Adv. 59, 107953 (2022).
Tong, Y.*, Jørgensen, T.S., Whitford, C.M., Weber, T.*, Lee, S.Y.* A versatile genetic engineering toolkit for E. coli based on CRISPR-prime editing. Nature Communications. 12, 5206 (2021).
Tong, Y.*, #, Zhang, J.#, Wang, L., Wang, Q., Huang, H., Chen, X., Zhang, Q., Li, H., Sun, N., Liu, G., Zhang, B., Song, F., Alterovitz, G., Dai, H.*, Zhang, L.* Hyper-synergistic antifungal activity of rapamycin and peptide-like compounds against Candida albicans orthogonally via Tor1 kinase. ACS Infectious Diseases. 7, 2826-2835. (2021).
Tong, Y.*, #, Zhang, J.#, Sun, N. #, Wang, X. #, Wei, Q., Zhang, Y., Huang, R., Pu, Y., Dai, H., Ren, B., Pei, G., Song, F., Zhu, G., Wang, X., Xia, X., Chen, X., Jiang, L., Zhang, J., Ouyang, L., Zhang, B., Jiang, Y., Liu, X., Calderone, R., Bai, F.*, Zhang, L.*, Alterovitz, G. Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p. Science Bulletin. 66, 1895-1905. (2021).
Tong, Y.*, #, Zhang, J.#, Sun, N. #, Wang, X. #, Wei, Q., Zhang, Y., Huang, R., Pu, Y., Dai, H., Ren, B., Pei, G., Song, F., Zhu, G., Wang, X., Xia, X., Chen, X., Jiang, L., Zhang, J., Ouyang, L., Zhang, B., Jiang, Y., Liu, X., Calderone, R., Bai, F.*, Zhang, L.*, Alterovitz, G. Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p. Science Bulletin. 66, 1895-1905. (2021).
Tong, Y., Whitford, C. M., Blin, K., Jørgensen, T. S., Weber, T.*, Lee, S. Y.* CRISPR-Cas9-based, CRISPRi, and CRISPR-BEST-mediated genetic manipulation in streptomycetes. Nature Protocols. 15, 2470-2502. (2020).
Tong, Y.*, Deng, Z.*, An aurora of natural products-based drug discovery is coming. Synthetic and Systems Biotechnology. 5, 92-96 (2020).
Tong, Y., Whitford, C. M., Robertsen, H. L., Blin, K., Jørgensen, T. S., Klitgaard, A. K., Weber, T.*, Lee, S. Y.* Highly efficient DSB-free base editing for streptomycetes with CRISPR-BEST. Proc. Natl. Acad. Sci. U.S.A., 116, 20366-20375 (2019).
Tong, Y., Weber, T.*, Lee, S. Y.* CRISPR/Cas-based genome engineering in natural product discovery. Nat. Prod. Rep. 36, 1262-1280 (2019). Journal cover paper.
Tong, Y.*,#, Liu, M.#, Zhang, Y., Liu, X., Huang, R., Song, F., Dai, H., Ren, B., Sun, N., Pei, G., Bian, J., Jia, X-M., Huang, G., Zhou, X., Li, S., Zhang, B., Fukuda, T., Tomoda, H.,Ōmura, S., Cannon, R.D., Calderone, R., Zhang, L.* Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters. Synthetic and Systems Biotechnology. 1, 158-168. (2016).
Best innovation award of Novo Nordisk Foundation Center for Biosustainability, 2015
浦江創新論壇-尋找青年的聲音2021
現授“生命科學前沿🧬：合成生物學”（研究生）🩱，春季學期-
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