神經退行性疾病與睡眠障礙
本實驗室主要以果蠅和小鼠為模式動物，致力於發現調控果蠅睡眠和節律的 神經環路和關鍵基因🧑🦳，並探討神經系統疾病模式動物中相關病理機製（如睡眠/節律紊亂、 社交障礙等），EON体育4平台將在小鼠體內進行深入驗證與拓展。實驗室綜合運用遺傳學👩💻、分子生物 學🔱、鈣成像、電生理和行為學等技術進行多層面研究🤘🏽，考慮到信號通路、調控機製和生理過 程從果蠅到哺乳類均具有高度保守性，期待這些工作為動物行為的神經生物學基礎和調控機 製（穩態維持與失去）提供新的認識與見解。
課題負責人🐭： 平勇，博士生導師，副研究員，PI😋，當選上海科技啟明星👳♂️，目前主持國家自然科學基金面上基金等多項課題🦻🏽。
在讀學生：
張妍，李慜哲，邵淩展🧑🏼🦰，牟楊，楊璐娜，杜和楊🧥，易昕（聯合培養），龐傑（聯合培養）
歡迎對睡眠和神經退行性疾病感興趣的本科生和研究生加入本課題組，為探究一些重要科學問題EON体育4平台一起奮鬥。如有意向請聯系yoping@@sjtu.edu.cn （發郵件時請去掉一個@），會安排後續面談等🧚♂️。
代表性論文🏃♂️🏄🏼：
1. Feng G, Song Q, Zhang J, L Shao, Li M, Yang L, Ping Y* (2018) Control of sleep onset by Shal/Kv4 channels in Drosophila circadian neurons. Journal of Neuroscience 38(42):9059-9071
2. Song Q, Feng G, Zhang J, Xia X, Ji M, Lv L, Ping Y* (2017) NMDA Receptor-mediated Ca2+ Influx in the Absence of Mg2+ Block Disrupts Rest:activity Rhythms in Drosophila. SLEEP 40(12):1-13
3. Feng G, Pang J, Yi X, Song Q, Zhang J, Li C, He G, Ping Y* (2018) Down-regulation of KV4 channel in Drosophila mushroom body neurons contributes to Aβ42-induced courtship memory deficits. Neuroscience. 370:236-245.
4. Song Q, Feng G, Huang Z, Chen X, Chen Z, Ping Y* (2017) Aberrant axonal arborization of PDF neurons induced by Aβ42-mediated JNK activation underlies sleep disturbance in an Alzheimer's Model. Molecular Neurobiology. 54(8):6317-6328.
5. Ping Y, Hahm ET, Waro G , Song Q, Vo-Ba DA, Licursi A, Bao H, Ganoe L, Finch K, Tsunoda S* (2015). Linking Aβ42-Induced Hyperexcitability to Neurodegeneration, Learning and Motor Deficits, and a Shorter Lifespan in an Alzheimer's Model. PLOS Genetics 11(3):e1005025.
6. Ping Y and Tsunoda S (2012). Homeostatic plasticity in Drosophila central neurons, and implications in human diseases. Fly 1;6(3).
7. Ping Y & Tsunoda S* (2012). Inactivity-Induced Increase in nAChRs Up-Regulates Shal K+ Channels to Stabilize Synaptic Potentials. Nature Neuroscience 15:90-97.
8. Ping Y, Waro G, Licursi A, Smith S, Vo-Ba DA, Tsunoda S* (2011) Shal/K(v)4 channels are required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. PLoS One 6:e16043.
9. Yang XF, Miao Y, Ping Y, Wu HJ, Yang XL, Wang Z* (2011) Melatonin inhibits tetraethylammonium-sensitive potassium channels of rod ON type bipolar cells via MT2 receptors in rat retina. Neuroscience 173:19-29.
10. Ping Y, Huang H, Zhang XJ, Yang XL* (2008) Melatonin potentiates rod signals to ON type bipolar cells in fish retina. Journal of Physiology 586:2683-2694.
