主講人簡介：

英國約翰英納斯中心研究組長，東安格利亞大學教授，英國皇家學會院士（Fellow，FRS）👩🏿‍🦲，歐洲分子生物學組織成員（Fellow，EMBO），美國科學促進會會士（Fellow，AAAS）。曾任《The Plant Cell》期刊主編👩🏿‍🦳，歐洲植物科學組織（EPSO）副主席💇，現任《Plant Physiology》期刊副主編，《Current Opinion in Plant Biology》、《Trends in Plant Sciences》等多個學術刊物編委。

長期從事植物代謝的分子生物學研究，關註飲食與人類健康的關系，致力於通過植物代謝工程及生物強化，提升植物性膳食來源的營養價值，以應對全球範圍內慢性疾病不斷加劇的挑戰🤳🏻。關註植物天然產物的合成與調控🤒，特別是中國藥用植物中用於治療或輔助治療癌症的代謝產物⛓。在國內外學術刊物發表研究論文300余篇，參與撰寫學術專著40余部🔯，並獲得多項專利🫳🏿。

獲得營養學蘭克獎（Rank Prize for Nutrition）🔱🦵，多酚研究成就獎（Groupe Polyphenols Prize）👧🏼，英國生物技術與生物科學研究委員會最具潛力創新者獎（BBSRC Most Promising Innovator）。2014年👨🏽‍🎓，因對植物生物技術的貢獻被授予大英帝國勛章（MBE）。

報告摘要：

Plant natural products may occupy parts of the chemical space largely unexplored by screening of available pharmaceutical libraries while at the same time adhering to ‘drug-likeness’ descriptors. While there remains interest in developing small molecule drugs for cancer, exploring large numbers and diverse types of druglike compounds is a challenge. However, new chemical leads can be identified from traditional medicines, where long-standing ethnobotanical usage supports more detailed investigation. Scutellaria barbata D. Don is a key medicinal plant species in the Lamiaceae (the mint family) and the aerial parts have been used traditionally for treating cancer in many Asian countries, where it is known as Ban Zhi Lian (半枝蓮). Scutebarbatine A is the major diterpenoid, produced in specialized large, peltate trichomes on leaves of S. barbata. It induces dose-dependent apoptosis, specifically in cancer cells. Comparison between the cytotoxicity of methanolic extracts of S. barbata leaves and decoctions (Ban Zhi Lian) prepared traditionally, showed substantially different chemical compositions and differential induction of apoptosis. Analyses suggest polyvalency between the constituents in both extracts, and ways to produce enhanced chemopreventive preparations for the treatment of cancer.