報告人：白凡

             北京大學生物醫學前沿創新中心(BIOPIC)🦘、北京未來基因診斷高精尖創新中心(ICG)、生命科學EON4研究員/正教授

報告時間🕵🏼‍♂️：2023年3月23日👨🏽‍🚒，9:30-11:00

報告地點：生物藥學樓樹華多功能廳

報告人簡介：

現任北京大學生物醫學前沿創新中心(BIOPIC)、北京未來基因診斷高精尖創新中心(ICG)📎、生命科學EON4研究員/正教授👨🏻‍🦯。白凡實驗室致力於創新和應用單細胞、單分子技術，探索生物醫學前沿交叉領域😿📻，關註癌症發生、基因突變和轉移機製，關註細菌致病和抗生素耐藥的分子機製。已在Science (2篇)𓀝，Nature🤞🏼，Cell (2篇)，Cancer Cell，Nature Immunology，Molecular Cell (2篇)等著名學術期刊發表論文100余篇。曾獲得中組部“青年海外高層次人才”計劃，基金委優秀青年基金(2017)、傑出青年基金(2021)資助。以課題負責人身份多次獲得科技部863計劃、“精準醫學”重點研發計劃、科技重大專項資助，獲得國家科技進步二等獎，中國細胞生物學學會-青年科學家獎，樹蘭醫學青年獎，中源協和創新突破獎🪰。研究成果獲Cell雜誌社2019年中國年度論文，獲2019年中國臨床醫學十大進展🚵🏼‍♀️。

報告摘要：

      Liquid-liquid phase separation is emerging as a crucial phenomenon in several fundamental cell processes. A range of eukaryotic systems exhibit liquid condensates. However, their function in bacteria, which, in general, lack membrane-bound compartments, remains less clear. Here, we used high-resolution optical microscopy to observe single bacterial aggresomes, nanostructured intracellular assemblies of proteins, to undercover their role in cell stress. We find that proteins inside aggresomes are mobile and undergo dynamic turnover, consistent with a liquid state. Our observations are in quantitative agreement with phase-separated liquid droplet formation driven by interacting proteins under thermal equilibrium that nucleate following diffusive collisions in the cytoplasm. We have found aggresomes in multiple species of bacteria and show that these emergent, metastable liquid-structured protein assemblies increase bacterial fitness by enabling cells to tolerate environmental stresses.