講座時間：2020年11月11日上午9:30

講座地點：EON体育4閔行校區 生命藥學樓樹華報告廳

主 講 人：魏文勝 北京大學EON体育4平台

主辦單位🏄🏼‍♂️：EON体育4平台

聯 系 人🙇🏻‍♂️🤬：邢海娜 (xinghaina@sjtu.edu.cn)

主講人簡介🌎：

魏文勝，北京大學生命科學EON4教授，目前同時擔任北京大學生物醫學前沿創新中心（BIOPIC）、北京未來基因診斷高精尖創新中心（ICG）及北大-清華生命科學聯合中心（CLS）研究員🏌🏿‍♂️，任北京大學基因組編輯研究中心主任。課題組致力於發展基於基因組編輯技術的高通量功能基因組學💔、開發新型基因編輯技術並應用於基因治療🙄，研究癌症、感染等重大疾病發生機製⚓️，為發展高效治療手段提供新的藥物靶點和思路🤟🏻。

內容簡介👩‍🔬：

We have previously developed a series of high-throughput screening (HTS) methods based on CRISPR/Cas9 system for the functional identification of protein-coding genes and long non-coding RNAs. We have also re-designed sgRNA scaffold that greatly boosts the efficiency and data quality for HTS. Our recent efforts include the identification of functional 3D-hubs that were essential for cell viability, the development of a new approach for mapping functional sites of protein of interest at single amino acid resolution, and a series of novel high-throughput strategies derived from base editors. Besides these high-throughput strategies to facilitate the accurate and rapid identification of functional genomic elements in various settings, we have recently developed a novel programmable RNA editing strategy called LEAPER. Unlike conventional nucleic acid editing technology that requires simultaneous delivery of editing enzymes (such as Cas protein) and guide RNAs into cells, LEAPER enables precise and efficient RNA editing by recruiting endogenous cellular deaminase using engineered RNAs.  

請感興趣的老師於2020年11月10日16:00前掃描以下二維碼報名🔭。