報告題目： Mechanisms that mediate the temporal organization of memories in the hippocampus

主講人：Alcino J Silva

報告時間：4月19日（周五）10:30-11:30

報告地點：閔行校區EON体育4平台1號樓105會議室

聯系人🔯：李衛東

主講人簡介🤹🏻：

Alcino J Silva, Departments of Neurobiology, Psychiatry, and Psychology, Integrative Center for Learning and Memory, Brain Research Institute, University of California, Los Angeles, California 90095, USA

報告簡介🤸：

Studies of the molecular, cellular and circuit mechanisms of learning and memory have focused almost exclusively on how single memories are acquired, stored and edited. By comparison, very little is known about the mechanisms that mediate the temporal organization of memories in the hippocampus. Recently, our laboratory used state of the art in vivo imaging methods, chemogenetic and optogenetic approaches in the hippocampus and retrosplinial cortex, to uncover mechanisms that open and close the window for the organization of memory across time. Interestingly, we showed that aging disrupts these mechanisms and that this results in age dependent decline in how memories are linking across time. Importantly, studies in our laboratory have also identified strategies to rescue these deficits.