報告題目：Molecular and Cellular Mechanisms of Stem Cell Aging

報  告 人😇：秦昭⛹🏻‍♂️，同濟大學醫EON4教授🎤，博士生導師。

報告時間🦻🏿🙌🏼： 6月22日  14:00-15:00

報告地點：閔行校區生物藥學樓三號樓2層教工之家

聯  系 人：謝雲 34207401

報告人簡介：秦昭，同濟大學醫EON4教授🫸🏿🤞🏼，博士生導師🫷。2004年畢業於EON体育4🧖🏽，獲生物技術系學士學位。2010年畢業於美國密歇根大學👨🏼‍🎤，獲分子細胞發育生物學系博士學位。博士期間以斑馬魚為模型，研究神經再生的分子機製。2010年至2016年在美國紐約大學醫EON4進行博士後訓練，以線蟲的生殖幹細胞為模型，從事幹細胞衰老機製的研究工作。秦昭教授的實驗室運用線蟲和小鼠等模式動物研究衰老機製，主要關註生殖系統和神經系統：包括生殖幹細胞和神經幹細胞的衰老機製🧿、生殖衰老（卵細胞質量控製等）的機製🌰💁🏿、神經退行性疾病的致病機理和治療手段的研究。

報告簡介：Stem cells maintain tissues and organs over the lifespan of individuals. Consequently, age-associated stem cell decline affects the normal function and regenerative capacity of many tissues and organ systems, contributing to aging at the organismal level. Therefore, a better understanding of the molecular and cellular control of stem cell aging is required. My lab uses the C. elegans germ line as a model to study the effect of age on stem cells. Previous work from my postdoc studies showed that reducing insulin/IGF-1 signaling suppresses age-related loss of germline stem cells and that this effect requires the downstream FOXO transcription factor DAF-16. Surprisingly, DAF-16/FOXO is required in cells at the proximal region of the somatic gonad, a region that contacts the differentiated progeny of germline stem cells, suggesting a novel mechanism of stem cell regulation at the organ system level. In my own lab, I plan to investigate the nature of germline stem cell regulation by DAF16/FOXO activity in the proximal somatic gonad and to identify and characterize new genes that regulate age-related germline stem cell loss. Together, we hope our studies will not only greatly advance our understanding of the mechanisms that underlie age-related germline stem cell loss in C. elegans, but also contribute to our knowledge of stem cell aging in general.