報告題目：Control of Adaptive Immunity by Evolutionarily Co-opted  Signaling Pathways

報告人：Ming Li, PhD

報告時間👩🏿‍🎨：2012.10.23  PM 3👩‍🌾：00-4:00

報告地點： 3rd floor meeting room, Building 5, School of Medicine, SJTU, 280 South Chongqing Road, HuangPu District, Shanghai

聯系人：馬小京

報告人簡介：

Dr. Li graduated from Fudan University in 1993, and got his Master Degree from Shanghai Institute of Biochemistry in 1996. Then he obtained his PhD Degree in Columbia University in 2001 and went on doing the Postdoc in Yale University till 2007. Dr. Ming Li is now the Assistant Member of Memorial Sloan-Kettering Cancer Center (MSKCC) and the Assistant Professor of Cornell University.

報告人研究方向4️⃣：

Elucidation of the mechanisms underlying T cell regulation in the immune system steady state and upon pathogen invasion is fundamental to the understanding of immune system function, and for the design of therapeutics to target faulty immune responses. A major focus in Dr. Ming Li’s lab is to study how evolutionarily ancient signaling pathways are rewired to regulate the highly specialized T cell activities. Using genetically engineered mouse models, they have found that the TGF-beta/TGF-beta receptor and Akt/Foxo pathways play crucial roles in the control of T cell development, homeostasis, and tolerance. Ongoing research in their lab aims to unravel the molecular and cellular mechanisms of such regulation, and to establish the functions of these signaling modules in autoimmune diseases, infectious diseases, and cancer.

報告人發表的代表性論文🫰🏽：

1. M.O. Li, Y.Y. Wan, S. Sanjabi, A.K.L. Roberson, R.A. Flavell. Transforming Growth Factor-beta Regulation of Immune Responses. Annu. Rev. Immunol. 2006, 24: 99-146.

2. M.O. Li, S. Sanjabi, R.A. Flavell. Transforming Growth Factor-beta Controls Development, Homeostasis and Tolerance of T Cells by Regulatory T Cell-dependent and -independent Mechanisms. Immunity 2006, 25: 455-471.

3. M.O. Li, Y.Y. Wan, R.A. Flavell. T Cell-produced Transforming Growth Factor-beta1 Controls T Cell Tolerance and Regulates Th1- and Th17-Cell Differentiation. Immunity 2007, 26: 579-591.

4. M.O. Li, R.A. Flavell. Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-beta and Interleukin-10. Immunity 2008, 28: 468-476.

5. M.O. Li, R.A. Flavell. TGF-beta: A Master of All T Cell Trades. Cell 2008, 134: 392-404.

6. W. Ouyang, O. Beckett, R.A. Flavell, M.O. Li. An Essential Role of the Forkhead-Box Transcription Factor Foxo1 in Control of T Cell Homeostasis and Tolerance. Immunity 2009, 30: 358-371. PMC2692529

7. W. Ouyang, O. Beckett, Q. Ma, M.O. Li. TGF-beta Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development. Immunity 2010, 32: 642-653. PMC:2880228

8. W. Ouyang, O. Beckett, Q. Ma, J. Paik, R.A. DePinho, M.O. Li. Foxo Proteins Cooperatively Control the Differentiation of Foxp3+ Regulatory T Cells. Nat Immunol 2010, 11: 618-627.

9. W. Ouyang, M.O. Li. Foxo: in Command of T-lymphocyte Homeostasis and Tolerance. Trends in Immunol. 2011, 32: 26-33. PMC:3053075

10. I. Gutcher, M. Donkor, Q. Ma, A.Y. Rudensky, R.A. Flavell, M.O. Li. Autocrine Transforming Growth Factor-beta1 Promotes in vivo Th17 Cell Differentiation. Immunity 2011, 34: 396-408.

11. Y. Chen, C.J. Haines, I. Gutcher, K. Hochweller, W.M. Blumenschein, T. McClanahan, G. Hammerling, M.O. Li, D.J. Cua, M.J. Mcgeachy. Foxp3+ Regulatory T Cells Promote T Helper 17 Cell Development in vivo through Regulation of Interleukin-2. Immunity 2011, 34: 409-421.

12. C. Shi, T. Jia, S. Mendez-Ferrer, T.M. Hohl, N.V. Serbina, L. Lipuma, I. Leiner, M.O. Li, P.S. Frenette, E.G. Pamer. Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands. Immunity 2011, 34: 590-601. PMC:3081416

13. M.K. Donkor, A. Sarkar, P.A. Savage, R.A. Franklin, L.K. Johnson, A.A. Jungbluth, J.P. Allison, M.O. Li. T Cell Surveillance of Oncogene-induced Prostate Cancer is Impeded by T Cell-derived TGF-beta1 Cytokine. Immunity 2011, 35: 123-134.

14. W. Ouyang, W. Liao, C.T. Luo, N. Yin, M. Huse, M.V. Kim, M. Peng, P. Chan, Q. Ma, Y. Mo, D. Meijer, K. Zhao, A.Y. Rudensky, G. Atwal, M.Q. Zhang, M.O. Li. Novel Foxo1-dependent Transcriptional Programs Control Treg Cell Function. Nature 2012 (in press).